Hyperkinesis without the Frank-Starling mechanism in a nonischemic region of acutely ischemic excised canine heart.
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چکیده
منابع مشابه
Hyperkinesis without the Frank-Starling mechanism in a nonischemic region of acutely ischemic excised canine heart.
To determine the essential mechanism of increased systolic wall motion, i.e., hyperkinesis, in a nonischemic region (NIR) during acute ischemia, we simultaneously evaluated global and regional function of the excised, cross-circulated canine left ventricle connected to a volume servo pump before and after coronary occlusion. Regional areas were determined with pairs of orthogonal subendocardial...
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OBJECTIVE The goal of the present study was to examine the ability of failing myocardium to respond to enhanced preload with an increase in force development. METHODS The effect of various preload conditions (2.5-15 mN) on force development was studied in right ventricular trabeculae carneae from explanted human failing hearts with ischemic cardiomyopathy (ICM, n = 5, 42 preparations) or idio...
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In 1866 at Carl Ludwig's Physiological Institute at Leipzig, Elias Cyon described the influence of diastolic filling of the isolated perfused frog heart on ejection volume. A study performed at the institute of the effect of filling pressure on contraction amplitude was published in 1869 by Joseph Coats, based on a recording made by Henry P. Bowditch.
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Previous work suggests that titin-based passive tension is a factor in the Frank-Starling mechanism of the heart, by increasing length-dependent activation (LDA) through an increase in calcium sensitivity at long sarcomere length. We tested this hypothesis in a mouse model (N2B KO model) in which titin-based passive tension is elevated as a result of the excision of the N2B element, one of card...
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The mechanisms which determine the response of stroke volume to mild, moderate, and severe exercise were compared in nine dogs running on a level treadmill. The dogs ran for 3-minute periods at 3-^ mph (mild exercise), 6-8 mph (moderate exercise), and 10—14 mph (severe exercise). Heart rate increased from a standing control value of 107 ± 6 beats/min to 191 ± 10 beats/min in mild, 221 ± 8 beats...
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ژورنال
عنوان ژورنال: Circulation
سال: 1988
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.77.2.468